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Autonomic nervous system pharmacology powerpoint presentation
Various physiochemical properties the of drugs6. Pharmacology: It is the science of drugs as it dealswith the interaction of exogenously administeredchemical molecule (Drug) with living system.
Pharmacodynamic: what the drug does to body3 4.
It is the quantitative study of drug movement in,through and out of the body. Schematically process of pharmacokinetic:Transportation Absorption Distribution-storagereceptor metabolism free drugbinding :(Effect) excretion.
Drugs are transported across the membrane by:1.
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It is the fraction of the drug that reaches to systemiccirculation from a given dose in unchanged from inan unchanged form.
Intravenous route gives 100% bioavailability as itdirectly enters the circulation. The term bioavailability is generally used for drugsgiven through oral route.
Bioequivalent: Two formulation of the same drughaving equal bioavailability. Bioinequivalent: if formulation differ in therebioavailability.
General pharmacology - slideshare
extent of binding to plasma and tissue proteind.
Movement of the drug proceed until an equilibrium isestablished between unbound drug in plasma and tissue fluids.
It means chemical alteration of the drug in the body.
Primary sites of drug metabolism is liver , others are –kidney, intestine lungs and plasma. Biotransformation of drug may lead may lead to thefollowing:a.
Excretion is the removal of the drug and its metabolitefrom the body. It attemptsto elucidate the complete action-effect sequence and dose-effect relationship. Principles of drug action:drugs do not impart new function to any system , organ orcell they only alter the pace of ongoing activity.
Majority of the drugs produce their effect by interactingwith a discrete target biomolecule.
It is a single chemical entity present in a medicine thatis used for diagnosis, prevention, treatment/cure of adisease 24 Mar 2015 - Presentation Courses · PowerPoint Courses; by LinkedIn Learning Pharmacology: It is the science of drugs as it deals with the interaction of The term bioavailability is generally used for drugs given through oral route. Affinity: the ability of the drug to get bound to the receptor is known as affinity..
According to the WHO : Drug is any substance orproduct that is used or is intended to be used tomodify or explore physiological system or pathologicalstates for the benefits of the recipient. Receptor are (specific) protein and have specificity andselectivity .
No drug is truly specific but many havea relatively selective action on one type ofreceptor.
Drug+ receptor Drug –receptor complexResponse16 17 Professor Fink's Video Lecture; Welcome to Pharmacology for Dental Hygiene: http://www.youtube.com/watch?v=0hVaO1rlXus. Professor Fink's Video Lecture; .
Affinity: the ability of the drug to get bound to thereceptor is known as affinity. Intrinsic activity: The ability of the drug to produce apharmacological action after combining with thereceptor.
Agonist: A drug that is capable of producingpharmacological action after binding to the receptor. Antagonist: drugs that bind to receptor but are notcapable of producing pharmacological action.